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KMID : 0360120110330060467
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Journal of the Korean Society of Maxillofacial Plastic Reconstructive Surgeons
2011 Volume.33 No. 6 p.467 ~ p.477
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The Effect of Low-intensity Pulsed Ultrasound on Osteogenesis in Mini-pig Mandibles
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Yun Yeong-Eun
Lee Jun
Min Seung-Ki
Kim Sang-Jung
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Abstract
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Purpose: The objective of this study was to examine the affected period and the amount of bone formation during osteogenesis of intramembranous bone using low-intensity pulsed ultrasound (LPUS) in vivo.
Methods: Xeno-bone (Bio-oss) and autogenous bone were grafted bilaterally into mini-pig mandibles. The left mandible served as the control and the other mandible was treated with 3 MHz, 160 mW (output, 0.8 mW) ultrasound stimulation for 7 days 15 minutes per day. The mini-pigs were sacrificed at 1, 2, 4, and 8 weeks, and micro computed tomography (microCT), a microscopic examination, and a statistical analysis were performed on the specimens.
Results: Based on a computerized image analysis of the microCT scans, the experimental group had an average 150% more new bone formation than that in the control group. The effect of LPUS continued during the post operative 2 weeks. The histomorphological microscopic examination showed similar results.
Conclusion: Our results suggest the LPUS had an effect on early intramembranous bone formation in vivo.
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KEYWORD
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Low-intensity pulsed ultrasound, in vivo, Intramembranous bone, μCT
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